Teresa M. Gunn, PhD
Professor
Gene Editing and Mutant Mouse Assessment (GEMMA) Core Facility Director
Research Interests
Mouse models of disease.
Molecular mechanisms of neurodevelopment and neurodegeneration.
Mosmo-MEGF8-Mahogunin Ring Finger-1 (MMM) complex in left-right patterning and congenital heart disease.
SOX10 signaling in CNS development.
-
Education
McGill University, BS, Biology (1990)
University of British Columbia, PhD, Genetics (1996)Positions
1995-2001 | Postdoctoral Fellowship, Stanford University, Palo Alto, CA
2001-2006 | Assistant Professor, Dept of Biomedical Sciences, Cornell University, Ithaca, NY
2006-2009 | Robert Hovey Udall Assistant Professor, Dept of Biomedical Sciences, Cornell University, Ithaca, NY
2009-2021 | Associate Professor, McLaughlin Research Institute
2009-Present | Director, McLaughlin Research Institute Transgenic Facility
2021-Present | Professor, McLaughlin Research Institute
2023-Present | University College of Osteopathic Medicine, Professor, Touro University College of Osteopathic Medicine, Montana
2024-Present | Director, Gene Editing and Mutant Mouse Assessment (GEMMA) Core, McLaughlin Research Institute Center for Integrated Biomedical and Rural Health Research
2024-Present | Adjunct Professor, Touro University College of Osteopathic Medicine, Middletown, NY
Professional Activities
1995-present | Member, International Mammalian Genome Society (IMGS); Nominations and Elections Committee (2006-2008); Secretariat (2010-2012 and 2023-2026); President Elect/President/Past President (2012-2018)
2023-present | Member, International Transgenic Technology Society (ITTS)
2023-2027 | Member, Genetics of Health and Disease NIH study section
2023-2026 | Mouse Genome Database (MGD) Scientific Advisory Board
-
Ratz-Mitchem ML, Leary G, Grindeland A, Silvius D, Guter J, Kavanaugh MP, Gunn TM. Generation and characterization of a knock-in mouse model for Spastic Tetraplegia, Thin Corpus Callosum, and Progressive Microcephaly (SPATCCM). (2023) Mamm Genome 34(4):572-585. PMID: 37642681.
Barratt KS, Dai Y, Miller DR, Gunn TM, Siracusa LD (2023) 35th International Mammalian Genome Conference: meeting overview. Mamm Genome 34(3):449-452. PMID: 36867211.
Kong JH, Young CB, Pusapati GV, Espinoza FH, Patel CB, Beckert F, Ho S, Patel BB, Gabriel GC, Aravind L, Bazan JF, Gunn TM, Lo CW, Rohatgi R (2021) Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength. Development 148(19). PMID: 34486668.
Kong, JH, Young, CB, Pusapati, GV, Patel, CB, Ho, S, Krishnan, A, Lin, J-HI, Devine, W, Moreau de Bellaing, A, Athni, TS, Aravind, L, Gunn, TM, Lo, CW, Rohatgi, R (2020) A Membrane-Tethered Ubiquitination Pathway Regulates Hedgehog Signaling and Heart Development. Dev Cell 55(4): 432-449. PMID: 32966817.
Gunn, TM, Silvius, D, Lester, A and Gibbs, B (2019) Chronic and age-dependent effects of the spongiform neurodegeneration-associated MGRN1 E3 ubiquitin ligase on mitochondrial homeostasis. Mamm Genome 30(5-6): 151-165. PMID: 31089807.
Walker WP, Oehler A, Edinger AL, Wagner KU, Gunn TM. (2016) Oligodendroglial deletion of ESCRT-I component TSG101 causes spongiform encephalopathy. Biol Cell 2016 Jul 13. doi: 10.1111/boc.201600014. PMID:27406702.
Anderson, SR, Lee, I, Ebeling, C, Stephenson, DA, Schweitzer, KM, Baxter, D,Moon, TM, LaPierre, S, Jaques, B, Silvius, D, Wegner, M, Hood, LE, Carlson, G,Gunn, TM (2015) Disrupted SOX10 function causes spongiform neurodegeneration in gray tremor mice. Mamm Genome 26(1-2):80-93. PMID:25399070.
Besio R, Maruelli S, Gioia R, Villa, I, Grabowski, P, Gallagher, O, Bishop, NJ,Foster, S, De Lorenzi, E, Colombo, R, Diaz, JL, Moore-Barton, H, Deshpande, C,Aydin, HI, Tokatli, A, Kwiek, B, Kasapkara, CS, Adisen, EO, Gurer, MA, DiRocco, M, Phang, JM, Gunn, TM, Tenni, R, Rossi, A and Forlino, A (2015) Lack of prolidase causes a bone phenotype both in human and in mouse. Bone 72: 53-64.PMID: 25460580.
Gunn, TM and Carlson, GA (2013) RML prions act through Mahogunin and Attractin-independent pathways. Prion 7(4): 267-71. PMID: 23787699
Silvius, D, Pitstick, R, Ahn, M, Meishery, D, Oehler, A, Barsh, GS, DeArmond, SJ,Carlson, GA, Gunn, TM (2013) Levels of the Mahogunin Ring Finger 1 E3 ubiquitin ligase do not influence prion disease. PLOS-One 8(1): e55575. PMID:23383230
Gunn, TM, Silvius, D, Bagher, P, Sun, K, Walker, KK (2013) MGRN1-dependentpigment-type switching requires its ubiquitination activity but not its interaction with TSG101 or NEDD4. Pigment Cell Melanoma Res. 2013 26(2): 263-68. PMID:23253940
View all of Dr. Gunn’s publications at: